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Administration of GEP44 resulted in potent anorectic effects in two-to-five-day treatment studies in both lean and diet-induced obese (DIO) rats

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We selected the CAG-C9-3 line for subsequent experiments

Furthermore, compound R487E + V488E mutations, which interfere with the nuclear import of TRIM28, 41 also disrupted nuclear accumulation of TRIM37 (Fig

Loss of SLC33A1 leads to GSSG accumulation and a hyperoxidizing ER environment, which impairs non-native disulfide resolution and causes misfolded protein accumulation