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Gradual titration is critical to minimize gastrointestinal side effects [6]
In plain terms, it is the process in which healthy tissue cells turn into rigid, scar-producing cells, which in turn causes heart stiffness or cardiac fibrosis
While much of the available data comes from preclinical studies, interest in its biological activity continues to grow due to its interaction with multiple physiological pathways
There are also cases where patients with low B12 levels have problems with fertility or are more likely to develop dementia
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