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doi: 10.3390/biomedicines10081989 33 CarminaELongoRA

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In the published Phase 1/2 data, the clinical signature is consistent with that pharmacology: strong appetite suppression (GLP-1R-mediated), preserved glycemic control and improved tolerability versus pure GLP-1 agonists at equivalent weight-loss doses (GIPR-mediated), and meaningful thermogenic/fat-oxidation contribution above and beyond dual GLP-1/GIP activity (GCGR-mediated)

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