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A 2014 pharmacokinetic study demonstrated that ketoconazole (a strong CYP3A4/P-gp inhibitor) increased apixaban AUC by approximately 100%, while rifampin (a strong inducer) decreased it by roughly 54% [1]
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Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles
Medical organizations treat obesity like other chronic conditions meaning some patients genuinely benefit from longer-term medication, just as someone might stay on blood-pressure medicine
