While the mechanism of CV benefit for this medication class is unclear, it appears to occur through myriad processes, all of which are independent of glucose-lowering abilities
GLP-1 Supplements for Weight Loss: How to get started GLP-1 is a hormone your body naturally releases after meals to regulate appetite and blood sugar
Biochem Anal Biochem 6(1):308
Two numbers matter
For weight management , certain GLP-1 formulations (liraglutide 3.0mg [Saxenda] and semaglutide 2.4mg [Wegovy]) are licensed for chronic weight management in adults with: BMI 30 kg/m , or BMI 27 kg/m with at least one weight-related comorbidity (such as type 2 diabetes, hypertension, or dyslipidaemia) However, NHS access to these medications for weight management is typically restricted to specialist tier 3 or tier 4 weight management services, with specific eligibility criteria defined by NICE technology appraisals (TA494 for liraglutide, TA664 for semaglutide) and local commissioning arrangements
Once candidacy is established, treatment structure and monitoring determine how safely therapy can be delivered