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treatment of blood cells with lead resulted in ROS-independent eryptosis without any increase in ROS, but with an increase in Ca 2+ level and caspase-3 activity

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Indeed, it was clearly shown that the antioxidant N-acetyl-L-cysteine (NAC) can inhibit eryptosis in vitro [116] and significantly prolong the half-life of circulating mouse erythrocytes in vivo [72] presumably by interfering with efferocytosis of eryptotic cells