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Its ability to remain chemically intact in gastric conditions facilitates its use via oral, parenteral, or topical administration 2

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Importantly, the current evidence supporting this approach is largely indirect and derived from studies conducted in patients with established PsO and metabolic comorbidities, rather than in well-characterized early PsA cohorts.An additional and largely underexplored aspect concerns the safety of combining GLP-1RAs with bDMARDs

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These effects are achieved by reducing immunosuppressive myeloid cells, increasing effector T cells, and enhancing the production of citrulline and NO