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Statistical analysis The R v4.3.3 [45] package lme4 [46] was used to carry out the linear mixed model (LMM) with treatment (or test variable) as fixed effect and block as random effect, thanks to which phenotypical and -diversity data were analysed

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On day 4 or 6, macrophages were polarized with or without 100 ng ml 1 lipopolysaccharide (LPS) (Sigma) and 2050 ng ml 1 IFN (PeproTech) for 12 days

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