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1 Tirzepatide 15 mg: -11.2 kg average weight loss Injectable semaglutide 1 mg: -5.7 kg average weight loss HbA1c: -2.30% with tirzepatide 15 mg vs -1.86% with semaglutide 1 mg Rybelsus 14 mg (the highest available oral dose) produces roughly equivalent blood levels to injectable semaglutide 0.5-1.0 mg per week, which is at or below the injectable dose tested in SURPASS-2
10.1016/j.eplepsyres.2023.107190 16 CovolanL.SmithR.MelloL
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Results of all the confirmatory secondary outcomes were also more favorable for participants who received semaglutide and included a less steep decline in mean annual eGFR (difference, 1.16 mL/min/1.73m 2
A qualified assessmentpotentially including biomarker and genetic contextinforms this decision
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