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Oridonin, a diterpenoid compound isolated from Rabdosia rubescens , was shown to alleviate PI-IBS symptoms in rats by significantly inhibiting phosphorylation of NF-B p65 and downregulating downstream inflammatory mediators such as inducible nitric oxide synthase (iNOS), COX-2, IL-1, and IL-6

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Cys151 residue is required to inhibit Keap1-mediated Nrf2 degradation, thus itaconate upregulates Nrf2 levels via Keap1 alkylation ( Figure 3 )

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