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In addition, LEADER, SUSTAIN-6, HARMONY, PIONEER 6, REWIND, and AMPLITUDE-O found that GLP-1RAs had cardioprotective effects independent of their ability to lower blood glucose levels
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While I wish they had shown the actual rather than cumulative distribution here, you can get a sense of this weight loss variability from the figure below: Source: Ryan, D.H., Lingvay, I., Deanfield, J
Even when dietary intake drops, urinary losses stay minimal
SLU-PP-332 mechanism: peripheral action (muscle, BAT, liver) on oxidative energy expenditure
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