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If significant deficiency is confirmed via blood test, a loading dose protocol may be recommended in line with NICE guidance typically more frequent injections over the initial weeks to rapidly restore levels

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In addition, it is crucial for the functioning of the central nervous system, along with the absorption and metabolism of fats and carbohydrates

If this happens, the integrity of the compound is compromised, and for research purposes, it should ideally be discarded to avoid skewed results

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Therefore, future studies must focus on the proper design to diminish the possible sources of bias