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Low oxygen levels (ischemia) can develop in the retina, leading to increases in inflammatory chemicals (such as vascular endothelial growth factor [VEGF], cytokines, and angiotensin II) and increases in blood pressure

The iron chelator DFO has been shown to decrease ROS production, mitigate hemoglobin-induced neurotoxicity, reduce brain edema, and enhance functional outcomes in both in vivo and in vitro models of CH (Regan and Panter, 1996

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Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury