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Through the analysis of numerous in vivo and in vitro studies aimed at determining the mechanisms by which GLP-1 enhances insulin secretion in individuals with normal glucose tolerance or T2DM, two main intracellular mechanisms underlying the incretin effect have emerged
Current 2D models are very limited and physiologically inaccurate, and the data obtained from them may not translate to the in vivo setting, ultimately delaying the advancement of knowledge in this field
Meir E, Yagil E
Insert air into the vial: Remove the cap from the needle and push the needle through the rubber stopper at the top of the vial
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