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Future research should explicitly examine sex-specific efficacy and safety profiles of resmetirom and semaglutide as part of precision-medicine efforts
D+Q works by inhibiting pro-survival pathways (tyrosine kinases and Bcl-2 family) broadlythese pathways are also present in non-senescent cells, creating off-target effects
Hou BS et al
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In people with Hashimotos, this mechanism can be especially helpful
NICE guidance provides a clear framework for the management of obesity in the UK (NICE CG189: Obesity: identification, assessment and management) and for type 2 diabetes (NICE NG28: Type 2 diabetes in adults: management)
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