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As opposed to other organisms, for which these conditions would be deleterious, cavefish overcome the environmental challenges and maintain physiological health via metabolic adaptations, potentially contributing to reduced sleep phenotype in cavefish

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That observation, while from an in vitro model, anchors the theoretical basis for every clinical protocol in use today

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Ferrari, S., Plotnikova, J

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The fasting window matters Community protocols commonly describe dosing on an empty stomach, typically 1-2 hours after a meal and 20-30 minutes before eating again

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