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This study demonstrates that MTHFR deficiency indeed increases leukemic cell resistance to a variety of MYC-targeting pharmacological agents, including BET protein small-molecule inhibitors

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While the molecular alterations identified were robust and internally consistent, validation in larger, independent cohorts will be important to confirm our findings and assess inter-individual variability

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**Due to vial size limitations, Tiers 1, 2 and 3 plans will receive the same total mg, but will have different dosing instructions

if you dont control it, it can cause an avalanche of complications