Regardless of its origin, vitamin D undergoes two steps: first, in the liver, it is hydroxylated by 25-hydroxylase (CYP2R1) to form 25-hydroxyvitamin D [25(OH)D], and subsequently, in the kidney, it is hydroxylated by 1-hydroxylase (CYP27B1) to generate the biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D] (6)
Rodrigues et al
This targeted adaptation aligns with tissue-specific remodeling rather than generalized endocrine stimulation
This prolonged intracellular environment differentiates it from shorter-acting IGF variants
Body composition (DEXA or similar) only useful with a long enough window to detect change
10.1016/S0140-6736(85)91481-3 Ohtani Y, Endo F, Matsuda I: Carnitine deficiency and hyperammonemia associated with valproic acid therapy