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Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor
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In rare cases, it could be an early sign of cervical cancer
The conversation around obesity is shifting toward one of a chronic disease rather than a lifestyle choice
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