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Shi M, Liu L, Min X, Mi L, Chai Y, Chen F, et al

doi: 10.1186/s13018-021-02886-5 Summary Keywords cartilage, cell behavior, cell fate, chondrocytes, mitochondrial quality control, osteoarthritis Citation Li Y, Zhong W, Li L, Zhang F, Duan X and Si H (2026) Mitochondrial quality control modulating chondrocyte behavior and fate in knee osteoarthritis: mechanistic insights and therapeutic prospects

& Clerici, C

K., & Hassan, A

This upregulation means tissues become more responsive to the growth hormone already circulating in your body, amplifying repair signals without requiring additional hormone supplementation

Taking them together ensures that the "engine" of your cells (mitochondria) and the "fuel processors" (your gut bacteria) are both supported