semaglutide news november 28 2025 Suboptimal therapeutic responses associated with in type 2 diabetes and obesity: A meta-analysis of randomized controlled trials: Cell Reports Medicine When Joshua Hunt (@viajoshhunt) started

In 1987, GLP-1 (736) was recognized as a physiological incretin in the studies of Kreymann et al

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constructed sample-specific gene regulatory networks from healthy human tissues to reveal that many transcription factors have sex-dependent regulatory targets

Key risk factors include: Rapid weight loss: Losing weight quickly significantly increases gallstone risk Female sex: Women are two to three times more likely to develop gallstones than men Age over 40 years: Gallstone prevalence increases with age Obesity: Higher baseline BMI correlates with increased risk Previous history of gallstones: Prior biliary disease predicts recurrence Family history: Genetic factors contribute to gallstone susceptibility Certain ethnicities: Native American and Hispanic populations have higher baseline rates Estrogen exposure: Oral contraceptives, hormone replacement therapy, and multiple pregnancies Diabetes and dyslipidemia: Metabolic conditions affecting bile composition Prolonged fasting or TPN use: Reduces gallbladder contraction Patients should be educated about warning signs that may indicate gallstone complications

Key takeaway Specific probiotic strains such as Saccharomyces boulardii and Bifidobacterium lactis BB-12 can offer a supportive approach to managing GI side effects associated with GLP-1 receptor agonists