These unquenched free radicals then turn inward, attacking the mitochondria themselvesdamaging mitochondrial DNA, essential transport proteins, and inner-membrane lipids like cardiolipin
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Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-, and IL-1, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype ( 7.2 Ferroptotic cells program macrophage mobilization Many clinical diseases cause ferroptotic cell death, and macrophages are the primary effectors in ferroptotic cell clearance
Kamilaris CDC, Faucz FR, Voutetakis A, Stratakis CA
Glutathione injections are generally considered safe when administered by qualified healthcare professionals