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Retatrutide is a triple agonist acting on GLP-1, GIP, and glucagon receptors, distinguishing it from approved agents such as semaglutide or tirzepatide
It raises crucial questions about the sustainability of treatment effects and the practical implications of potentially indefinite therapy
Specifically, a decreased testicular organ index and altered indices of arterial blood gas and serum sex hormone levels caused testicular tissue morphological damage, reduced sperm quality, increased sperm deformity rate and altered malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) concentrations
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: BPC-157 , GHK-Cu ,
Cardiovascular benefits of native GLP-1 and its metabolites: an indicator for GLP-1-therapy strategies
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