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The investigators reported that Epithalon induced telomerase activity in cultures that were previously telomerase-negative, with corresponding increases in telomere length, and concluded that the peptide may extend cell-population lifespan through anti-senescence activity [1]

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Compared to the AFB 1 treatment, overexpression of GSTA2X, GSTA3, GSTT1L, GSTZ1-1, and GSTZ1-2 increased the cell viability by 6.5%17.0% in LMH cells

A minimum treatment duration of 36 months is recommended to achieve weight loss goals

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This overview is intended to contextualize existing findings, without suggesting subtype-specific therapeutic applications (Table 1)