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In astrocytes, LPS also increases NFB-mediated transcription of pro-inflammatory cytokines, including TNF, IL-1, iNOS and cyclooxygenase-2 (COX2) (Bobermin et al., 2020)
At the same time, ferroptosis was reported to result in lipid peroxidation of the endoplasmic reticulum (ER) [30]
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Human relevance would require sufficient published, peer-reviewed controlled human studies, safety evaluation, pharmacokinetic understanding, toxicology data, and regulatory reviewevidence that has not yet been established at the level required for clinical or consumer-use conclusions