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However, in animals, when the limits of adaptive responses are exceeded or do not occur in response to chemical exposure, irreversible cellular injury and cellular death occurs, with possible subsequent illness and death
One of the more surprising findings of the present studies was the relatively small amount of d 3 -BB found in plasma compared with d 3 -TMAO after d 3 -l-carnitine challenge, especially after ex vivo fecal studies showed that BB is a major metabolite of l-carnitine produced by human fecal polymicrobial cultures (43)
The 1:1 reflects equal mechanistic emphasis
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