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A 2021 study published in the New England Journal of Medicine (Wilding et al., NEJM, 2021) found that semaglutide 2.4 mg produced an average weight loss of approximately 14.9% of body weight over 68 weeks in adults with obesity, compared to 2.4% in the placebo group
However, a 2025 study found that people who used weight-loss medication regained weight more rapidly, with an average monthly weight regain of 0.4kg compared with 0.1kg in those who followed behavioural weight management programmes
Always follow your prescribed treatment plan and consult your clinician for medical decisions
UTEX 3222 is not GRAS yet as it was only discovered in 2023
The meta-analysis is interesting, but without the patient perspective and lived experience, it only tells part of the story
Once you reach your weight-management goals, your clinician may advise continuing treatment to help maintain your weight loss, as weight tends to be regained after stopping
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