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doi:10.3389/frph.2023.1143579 Maggio M, Ceda GP, Lauretani F, et al

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Dihexa is a small peptidomimetic that potentiates hepatocyte growth factor (HGF) signaling through the c-Met receptor at picomolar concentrations, demonstrating exceptional in vitro potency for promoting synaptogenesis

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Therefore, three factors cause excessive vasoconstriction: B2AdR dysfunction, excessive baroreflex activation due to hypovolemia, and excessive MMA activation due to the poor metabolic situation