It does not define an optimal dose, treatment duration, or patient-selection strategy for these secondary outcomes, and it does not resolve whether the pooled benefit reflects a true broad pharmacologic effect versus overlapping benefit from spasticity improvement itself, since spasm quality, bladder pressure, sleep, and gait can all be interrelated in MS
The program is designed to help people who have difficulty losing weight and are overweight or obese
The opposite effect fat and weight loss is at once the main purpose of AOD9604 and its observed effect in research
P.RiechersD
n = 1,961) and STEP 2 (NCT03552757
The sigma-1 receptor at the crossroad of proteostasis, neurodegeneration, and autophagy