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The documented synergy between GHRH and GHRP pathways across multiple preclinical models, combined with the matched temporal profiles and preserved selectivity of this specific combination, provides strong mechanistic rationale for their paired use

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In other words, long-term calorie restriction doesnt appear to directly reduce serum IGF-1 in humans (18)

Moreover, IGF-1 boosts bone healing and increases movement in patients with tibia and hip fractures [2]