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Ans : Slightly, with long-term use

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For instance, a randomized controlled trial published in the "Journal of Clinical Endocrinology & Metabolism" found that individuals treated with GLP-1 receptor agonists experienced greater weight loss compared to the control group

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Unlike other polyphenols, curcumin simultaneously inhibits NOX4-mediated superoxide burst and up-regulates NGF, providing a dual antioxidant-neurotrophic axis unique among plant polyphenols (Zhao et al., 2014