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To understand the non-monotone behavior of GSH, it is crucial to consider that there are two incoming fluxes to GSH, GS and GR, and two outgoing fluxes, GPX and a large flux out into the blood [Figure 2B]

Preclinical rodent studies support effects on angiogenesis, endothelial function, and nitric-oxide-related signaling, though these effects are reproducible in animals but not yet validated in humans

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