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(Peptide Sciences) FOXO4 expression is increased in senescent cells, and interfering with FOXO4 via shRNA or peptide competition leads to apoptosis of those cells
Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC Numbers 81672800, 81603009, 81673020, 81802632, and 82173830), Natural Science Foundation of Shaanxi (2020JQ-445), and the Key Research and Development Program of Shaanxi Province (2021SF-207, 2021SF-223, and 2022ZDLSF05-19)
They share the same receptor pathway, and doubling up dramatically increases the risk of severe gastrointestinal side effects without proportional benefit
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