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GLP-1 analogues are traditionally a class of antidiabetic medicines and include products Ozempic, Trulicity, Mounjaro, Wegovy, Rybelsus, Saxenda, Victoza, Xultophy, Soliqua, Zepbound, Bydureon, and others

This hormone helps regulate metabolism through several coordinated mechanisms: increasing glucose-dependent insulin secretion reducing glucagon release from the pancreas slowing gastric emptying in the stomach strengthening satiety signaling in the brain Together, these effects help improve blood sugar regulation and reduce calorie intake

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The combination does have theoretical synergy for body recomposition GLP-1 driving fat loss, IGF-1 LR3 preserving and building lean mass during caloric restriction

That overflow manifests as nausea, as well as other GI side effects like constipation and bloating