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Deferoxamine (DFO) was shown to negatively affect DNA synthesis and reduce cell growth in the leukemic cell line K562 by impairing the activity of ribonucleotide reductase (126)

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RRID:Addgene_72876)) for 48 h before seeding for flux analysis at 10,000 cells per well and allowed to adhere overnight in full culture media under normal conditions

reported significant enrichment of 15 REEs, including Ce, La, and Nd, in tumor tissues compared to adjacent normal tissues, suggesting a possible association with the lung cancer microenvironment, although the biological significance of this finding remains to be further clarified (78)

"These are potent medications, not supplements regular follow-up is essential." Both drugs also carry boxed warnings about thyroid C-cell tumors, a rare type of thyroid cancer seen in rodent studies

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