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Eur J Pharmacol 759:182191 Pulukool SK, Krishna S, Bhagavatham S, Kannan V, et al (2021) Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma

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Some people use lower doses during breaks rather than complete discontinuation, but this strategy lacks clinical validation

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