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Arai M, Imai H, Koumura T, Yoshida M, Emoto K, Umeda M et al

The cross docking of the identified hits with human GST revealed the potential binding specificity of the hits toward Wb GST

Furthermore, in spite of considerable research efforts (Dixon et al., We propose a model describing the diverse roles of plant GSTs in the interactions of plant hosts with pathogenic microbes considering four different plant-pathogen interaction types (Table 1): (1) symptomless resistance (including basal resistance to bacteria and symptomless R gene-mediated resistance to viruses), (2) HR-associated resistance, (3) limiting susceptibility to systemic spread of pathogens and plant cell/tissue death (during infections by hemibiotrophic/necrotrophic fungi, bacteria, and viruses), (4) promoting susceptibility to biotrophic fungi and viruses (maintaining reduced conditions in infected non-necrotic plant tissues)

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This regulation is particularly important in metabolically stressed cells, such as in hypoxia

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