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Clinical data shows tirzepatide users lose an average of 22.5% of their body weight, compared to 16.9% for semaglutide

However, the data also shows that once older adults are already engaged with GLP-1 treatment, resistance to tablets drops sharply: 43.19% say pills are more appealing than injections 64.94% of injectable users would consider switching This indicates the primary barrier among older adults may not be the pill format itself, but rather initial adoption of GLP-1 treatment in general

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Lancet, 2021

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