retatrutide molecular structure Shandong Jingtang Chemical RCSB PDB - 8YW3: Cryo-EM

Patients with a history of pancreatitis, gallbladder disease, multiple endocrine neoplasia syndrome type 2 (MEN 2), or of medullary thyroid cancer are generally not considered good candidates for Semaglutide GLP-1

doi: 10.1016/j.bcp.2020.114187 147 CapehornMSCatarigAMFurbergJKJanezAPriceHCTadayonSet al

Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this Article

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This mirrors the semaglutide profile, where the FDA label for Ozempic states no dose adjustment for renal impairment