Both injectable and nasal spray forms are used in practice, with the choice often depending on patient preference, treatment adherence, and desired intensity of effect
Long before microaneurysms, dot-blot hemorrhages, or hard exudates become visible on fundus photographs or ophthalmoscopy, the retina has already sustained measurable neuronal and synaptic loss, reactive gliosis, impaired neurovascular coupling, and subtle but objective deficits in contrast sensitivity, color discrimination, dark adaptation, and electrophysiological responses
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Combining medications requires sterile compounding conditions
Intracellular glutathione pools are heterogeneously concentrated