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Effects of the transient receptor potential vanilloid 1 antagonist A-425619 on body temperature and thermoregulation in the rat

This is a powerful, FDA-approved medication that mimics your bodies natural hormone supply of GLP-1

Journaling, meditation, spending time in nature, hanging out with loved ones, and engaging in physical activity (especially outdoors or with friends) all reduce cortisol levels and improve stress resilience

Sleep is so important

So the responsible way to approach it is as antioxidant support with realistic expectations, not as a guaranteed cosmetic result

Neuropharmacology 245 , 109815 (2023)