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For patients whose primary goal is fat loss and body composition improvement: Ipamorelin may be preferred due to its selective GH stimulation without cortisol elevation Cortisol is directly antagonistic to fat loss, particularly visceral fat The clean GH pulse from ipamorelin supports lipolysis without metabolic interference Sermorelin also supports fat metabolism through sustained GH improvement The best approach depends on individual factors including baseline hormone levels, cortisol status, and treatment goals

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Bottom Line If youre considering these medications, its essential to have a discussion with your healthcare provider to determine which option is best for you

However make sure you make your water easy to absorb, if you drink too much plain water you will deplete yourself of electrolytes

Early markers like improved glucose disposal and reduced postprandial fatigue precede visible body composition changes by several weeks