In connection with its high lipophilicity causing solubility problems ibuprofen poorly penetrates across the BBB
Key benefits Why people compare it 1 10 million times the synaptogenic potency of BDNF on a molar basis 2 Orally bioavailable peptidomimetic that crosses the blood-brain barrier 3 Promotes new dendritic spine formation in hippocampal CA1 neurons 4 Active at picomolar concentrations (10^-13 M) for cognitive enhancement 5 Reversed scopolamine-induced cognitive deficits in preclinical dementia models 6 Activates HGF/c-Met signaling via PI3K/Akt and Ras/MAPK cascades 7 Strengthens existing synaptic connections (long-term potentiation) 8 Protease-resistant design enables oral and subcutaneous administration Deep research About Dihexa Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a modified dipeptide analog with a molecular weight of approximately 507.63 Da
International Journal of Toxicology , 36(3_suppl), 5S-30S
Okuda H, Miwa K, Nojima H, Watabe T
In vitreous and extracellular matrix, GAGs maintain proper tissue properties and growth factor availability
If you have active asthma or reactive airway disease, discuss this risk thoroughly with your provider before proceeding
