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Intracellularly expressed scFv targeting mitochondrial CD147 inhibits lactate-induced stemness potentials in detached breast cancer cells To block the mitochondrial CD147-facilitated lactate uptake/oxidation and the induced stemness potentials in detached breast cancer cells, we intracellularly expressed a scFv specifically targeting mitochondrial CD147 (mito-CD147 scFv) by fusing a scFv sequence that targets CD147 to a matrix-targeting sequence that guides the scFv into mitochondria

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Zearalenone exposure tamps down the proinflammatory cytokines (TNF-alpha, IL1B, IL6) that should be produced in response to gram-negative bacteria

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Oxidative stress in breast cancer High levels of ROS have been identified in virtually all cancers, and ROS promote tumour development and progression

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