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Additional research is necessary to examine fracture reduction independent of weight loss. This research may also mainly pave the way for more research, rather than giving definite answers
PHQ-9, Patient Health Questionnaire 9
Most pharmaceutical semaglutide products like Ozempic and Wegovy avoid this confusion entirely by using pre-filled pens that deliver fixed doses
Probably the game-changing study in the New England Journal, which I was corresponding author on, was STEP 1, which actually launched semaglutide to the world which for the first time caused a result in a 15% weight loss at the end of a year
In contrast, resmetirom (Rezdiffra) received FDA approval in 2024 specifically for noncirrhotic NASH with F2F3 fibrosis
Most of the evidence for using them together comes from smaller clinical observations or the professional judgment of specialists who treat metabolic health
