Zepbound (tirzepatide) is FDA approved for weight loss and chronic weight management in adults with obesity, as well as adults who are overweight with at least one weight-related medical condition, such as high cholesterol or high blood pressure
With the emergence of clinical trials in non-diabetic patient populations demonstrating benefits of these agents in cardiovascular and renal outcomes, use of these drugs is anticipated to expand into the arsenal of nephrologists, cardiologists, and neurologists
Aspirin use was not significantly associated with stroke or major bleeding in either Lp(a) group
Pemvidutide Pemvidutide, another weekly GLP-1/glucagon dual agonist, is under evaluation in the ongoing phase 2 IMPACT trial (NCT05989711) in 190 individuals with histologically confirmed MASH and fibrosis stages F2-F3 [47]
Mounjaro, on the other hand, is a tirzepatide, or a gastric inhibitory polypeptide (GIP) analogue with mechanisms that overlap with that of semaglutide
Contrave works differently than GLP-1 medications (Wegovy, Zepbound) and differently than phentermine
