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The methods for Supplementary Figures can be found in the Supplementary Information
Tirzepatide and breastfeeding is a topic that requires careful discussion with a healthcare provider, and getting pregnant while on tirzepatide raises separate concerns about fetal exposure during the critical early weeks
183 However, preclinical research regarding the relative strength of estriol in terms of estrogen receptor activity and stimulation of breast cancer cells is ongoing and not all studies agree that estriol exerts weaker effects in this regard
But for certain people, it can genuinely make a positive difference
Watson K, Nasca C, Aasly L, McEwen B, Rasgon N (2018) Insulin resistance, an unmasked culprit in depressive disorders: promises for interventions