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Several research studies with rodents fed a high-fat diet, different animal models of obesity and diabetes, and patients diagnosed with T2DM have all shown changes in gut microbiota caused by metformin, as shown in Table 1

Novo Nordisk, the manufacturer of Ozempic and Wegovy, explicitly recommends once-weekly dosing and has not studied or endorsed any alternative schedules

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Thus, new therapeutic strategies should include targeting the IGF axis in malignant cells and tumor microenvironmental drivers in prostate cancer

These options are often considered when insulin resistance, ongoing fat retention, or weight loss plateaus limit progress