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In animal test models, reported side effects primarily relate to acute systemic vasodilation

GLP-1 RAs have shown antitumor effects via metabolic and immune modulation, reduced incidence of obesity-related cancers, and improved outcomes in some patients

Chiou, Senile cataracts and oxidative stress

In patients who are unable to tolerate drinking a lot of fluid by mouth, IV fluid becomes beneficial and sometimes life-saving. According to Chan, these are scenarios where fast fluids can make a big difference: After intense exercise, like a marathon After overheating, like in hot, humid weather After drinking too much alcohol After illnesses that cause extensive vomiting or diarrhea There are also some chronic conditions where this kind of fast hydration may be impactful

This happens because compressed discs and tight muscles pinch the nerves that run from the neck into the arms

Where they differ is in which receptors they target most strongly and that determines their primary effects