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The lower lip, in particular, receives years of unprotected sunlight in most people because lip sunscreen is rarely applied with the same diligence as facial sunscreen

In late August 2015, the US FDA issued a warning that drugs like sitagliptin, saxagliptin, linagliptin, alogliptin, and other DPP-4 inhibitors could cause joint pain that can be severe and disabling

CV risk factors were prevalent: 71% had a history of hypertension, 60% had hyperlipidaemia, and 14% reported current smoking

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